Related Experiment Video
Updated: Oct 23, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Leflunomide-induced interstitial pneumonitis: A rare occurrence in a case without underlying lung disease
V D Villgran1, E Rabold1, A Nasrullah2
1Pulmonary & Critical Care Medicine, Allegheny Health Network, Pittsburgh, PA, United States.
Abstract:
Pneumonitis from leflunomide is uncommon due to leflunomide's relatively favorable drug profile. Leflunomide-induced pneumonitis (LEIP) is a rare condition reported mainly in Asia. We present a case of LEIP from an accidental leflunomide overdose in the setting of concomitant methotrexate use and no underlying lung disease. Our patient was treated successfully with cholestyramine and steroids. Due to its high mortality, clinicians should be aware of this condition and its treatment.
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