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Updated: Oct 23, 2025

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

Cisplatin ototoxicity histopathology.

Sarah E Hodge¹, Ivan A Lopez², Gail Ishiyama³

¹House Ear Clinic Los Angeles California USA.

Laryngoscope Investigative Otolaryngology

|August 17, 2021

Summary

Cisplatin treatment for Hodgkin's lymphoma caused hearing loss by damaging the cochlea's organ of Corti. Vestibular organs showed minimal cisplatin effects, aligning with animal study findings.

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Area of Science:

Ototoxicology
Neuroscience
Oncology

Background:

Cisplatin is a chemotherapy agent used for Hodgkin's lymphoma.
Cisplatin is known to cause ototoxicity, leading to hearing loss and tinnitus.
The precise histopathological effects of cisplatin on human auditory and vestibular systems require further investigation.

Purpose of the Study:

To investigate the histopathological changes in the cochlea and vestibular end organs following cisplatin treatment for Hodgkin's lymphoma.
To determine the primary site of cisplatin-induced ototoxicity in humans.
To correlate human findings with existing animal models of cisplatin ototoxicity.

Main Methods:

Histopathological analysis of temporal bones from a patient treated with cisplatin for Hodgkin's lymphoma.

Keywords:

cisplatin ototoxicity temporal bone vestibular end organs

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Microscopic examination of the cochlea, focusing on the organ of Corti and its different regions.

Microscopic examination of the vestibular end organs (saccule, utricle, semicircular canals).

Main Results:

Significant histopathological damage was observed in the cochlea, particularly the organ of Corti at the base-hook region.
The observed cochlear damage is consistent with the known ototoxic effects of cisplatin and findings in animal models.
Minimal histopathological changes were noted in the vestibular end organs, suggesting a primary cochlear effect.

Conclusions:

Cisplatin's ototoxic effects are predominantly localized to the cochlea, specifically the organ of Corti.
The findings support the hypothesis that cisplatin-induced hearing loss is primarily a cochlear phenomenon.
This human case study provides valuable histopathological evidence supporting animal model data on cisplatin ototoxicity.