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Diastolic hypertension is associated with proteinuria in pediatric patients

Robert L Myette1,2, Dylan Burger2, Pavel Geier1

  • 1Division of Nephrology, Department of Pediatrics, Children's Hospital of Eastern Ontario University of Ottawa Ottawa Ontario Canada.

Health Science Reports
|August 17, 2021
PubMed

Insights

Pediatric patients with proteinuria showed significantly higher diastolic blood pressure. Proteinuria was a key predictor of elevated diastolic blood pressure in children.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Health in Children
  • Clinical Research

Background:

  • Proteinuria is linked to blood pressure lability in pediatric patients.
  • The precise impact of proteinuria on blood pressure requires further elucidation.

Purpose of the Study:

  • To analyze blood pressure and heart rate in pediatric patients with proteinuria.
  • To investigate the relationship between proteinuria and hemodynamic parameters in children.

Main Methods:

  • Retrospective chart review of pediatric patients (1-18 years) with idiopathic nephrotic syndrome.
  • Analysis of blood pressure and heart rate data in relation to anthropometric and biochemical parameters.
  • Inclusion of 72 urine sample analyses and associated blood pressure measurements from 33 children.

Main Results:

  • Diastolic blood pressure Z-scores were significantly higher in proteinuric patients (urine protein/creatinine >0.02 g/mmol) compared to non-proteinuric patients (P = .006).
  • Systolic blood pressure was also significantly higher in proteinuric patients (P = .04), but with a smaller effect size.
  • Proteinuria (>0.02 g/mmol) emerged as the most significant predictor of diastolic blood pressure elevation on multivariate analysis.

Conclusions:

  • A disproportionate increase in diastolic blood pressure versus systolic blood pressure was observed in pediatric patients with proteinuria.
  • Proteinuria is a significant factor influencing diastolic blood pressure in children with nephrotic syndrome.
Abstract

Keywords:
diastolic hypertensionpediatricsproteinuria

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