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Related Experiment Video

Updated: Oct 23, 2025

Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans

Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans

Published on: September 21, 2019

The Endocannabinoid System in Caenorhabditis elegans.

Rubén Estrada-Valencia^1,2, María Eduarda de Lima¹, Aline Colonnello¹

¹Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.

Reviews of Physiology, Biochemistry and Pharmacology

|August 17, 2021

Summary

The nematode C. elegans possesses a functional endocannabinoid system, despite lacking typical cannabinoid receptors. This system exhibits similarities to the mammalian endocannabinoid system, warranting further study.

Keywords:

Caenorhabditis elegans Cannabinoid receptors Endocannabinoid system Endocannabinoids N-acylphosphatidylethanolamine Nematodes

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Published on: September 7, 2017

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Last Updated: Oct 23, 2025

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Published on: September 21, 2019

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Published on: September 7, 2017

Area of Science:

Zoology
Neurobiology
Biochemistry

Background:

The existence of a formal endocannabinoid system in C. elegans has been debated due to the absence of canonical cannabinoid receptors.
However, C. elegans possesses a complete endocannabinoid metabolism, alternative ligands, and receptors.

Approach:

This review compares the endocannabinoid system in mammals and nematodes.
It highlights orthologous and homologous genes involved in cannabinoid-like signaling and responses.

Key Points:

Nematodes have a well-structured and functional complex system regulating physiological cannabinoid-like signals.
Several genes in C. elegans show similarity to those found in the mammalian endocannabinoid system.
The study emphasizes the presence of alternative ligands and receptors.

Conclusions:

Despite lacking typical receptors, C. elegans demonstrates a functional endocannabinoid system.
Comparing mammalian and nematode systems provides a basis for studying this novel system in C. elegans.