Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transferrin in chick retina: distribution and location during development.

G D Zeevalk1, A G Hyndman

  • 1Department of Biological Sciences, Rutgers University, Piscataway, NJ 08854.

Brain Research
|December 15, 1987
PubMed
Summary

Transferrin is present in developing chick retinas, particularly in Müller glial cells and photoreceptor outer segments. This suggests a role for transferrin in retinal development and iron storage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrastructural cytochemistry of monoamines in cultured human fetal sympathetic neurons.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2014
Same author

Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease.

Experimental neurology·2006
Same author

Rat model of Parkinson's disease: chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+).

Experimental neurology·2006
Same author

Mitochondrial inhibition and oxidative stress: reciprocating players in neurodegeneration.

Antioxidants & redox signaling·2005
Same author

Differential sensitivity of mesencephalic neurons to inhibition of phosphatase 2A.

The Journal of pharmacology and experimental therapeutics·2001
Same author

Hydrogen peroxide removal and glutathione mixed disulfide formation during metabolic inhibition in mesencephalic cultures.

Journal of neurochemistry·2001

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Ophthalmology

Background:

  • Transferrin is crucial for iron transport in the body.
  • Understanding transferrin's role in the retina is vital for comprehending visual system development and function.

Purpose of the Study:

  • To investigate the presence, location, and developmental changes of endogenous transferrin in chick retinas.
  • To explore the relationship between transferrin distribution and iron localization during retinal development.

Main Methods:

  • Immunocytochemistry was used to detect transferrin.
  • Retinal tissues from embryonic day 6 (E6) to 3 weeks post-hatching were analyzed.
  • Iron distribution was also examined.

Main Results:

Related Experiment Videos

  • Transferrin distribution varied with developmental age, appearing in Müller cell end-feet, inner and outer plexiform layers (IPL, OPL), nerve fiber layer (NFL), and photoreceptor outer segments.
  • Iron was primarily localized to Müller cell end-feet, not in synaptic layers or photoreceptor outer segments.
  • Transferrin immunoreactivity was strongest in photoreceptor outer segments and OPL in post-hatching chicks.

Conclusions:

  • Retinal glia may function in iron storage.
  • Transferrin likely plays a role in neuronal development and differentiation within the developing retina.