Related Experiment Video
Updated: Oct 23, 2025
08:30
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
13.3K
Aiding Adherence to Glaucoma Medications: A Systematic Review
Kristen L Buehne1, Jullia A Rosdahl1, Kelly W Muir1,2
1Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
Seminars in Ophthalmology
|August 17, 2021
Summary
Strategies to improve glaucoma medication adherence were reviewed. While many interventions showed improved adherence, few demonstrated significant clinical benefits like reduced intraocular pressure (IOP) or better visual field progression.
Area of Science:
- Ophthalmology
- Public Health
- Behavioral Science
Background:
- Glaucoma medication adherence is crucial for disease management.
- Poor adherence leads to increased intraocular pressure (IOP) and vision loss.
- Effective strategies are needed to improve patient compliance.
Purpose of the Study:
- To comprehensively assess strategies aimed at enhancing glaucoma medication adherence.
- To evaluate the effectiveness of interventions in improving patient compliance.
Main Methods:
- Systematic literature review of MEDLINE, Embase, and Scopus databases.
- Inclusion of studies from inception to March 1, 2021, focusing on adherence strategies.
- Categorization of identified strategies into five groups.
Main Results:
- 42 studies (50 papers) were included, identifying five strategy categories: reminder systems, medication simplification, behavioral programs, education, and alternative engagement.
- 26 of 42 studies reported improved medication adherence.
- Only three studies demonstrated an improvement in intraocular pressure (IOP); none showed improved visual field progression.
Conclusions:
- While various strategies can improve glaucoma medication adherence, clinical benefits such as IOP reduction are inconsistently observed.
- Further research is needed to link adherence interventions to meaningful clinical outcomes like visual field preservation.
More Related Videos
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
769
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
769
01:25Glaucoma: Overview
998
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
998
01:28Angle Closure Glaucoma: Treatment
898
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
898
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
34
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
34