Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

1.4K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.4K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

10.2K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
10.2K
Introduction to Hemostasis01:05

Introduction to Hemostasis

10.2K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
10.2K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

7.8K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
7.8K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.1K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.1K
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

348
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
348

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current concepts on feeding the critically ill patient: a narrative review.

Critical care (London, England)·2026
Same author

Postpartum Acquired Hemophilia A in Two Women With Previously Undiagnosed Carrier Status for von Willebrand Disease Type 2N and Heterozygous p.R854Q Mutation.

Haemophilia : the official journal of the World Federation of Hemophilia·2026
Same author

Duplication of the prothrombin gene is associated with a significant increase in thrombin generation.

Research and practice in thrombosis and haemostasis·2026
Same author

Albumin Replacement Therapy in Septic Shock: A Randomized Clinical Trial.

JAMA network open·2026
Same author

Revisiting clinical response and refractoriness in immune thrombotic thrombocytopenic purpura.

Blood·2026
Same author

The influence of thrombophilia and low molecular weight heparin on D-Dimer levels in women with high-risk pregnancy.

Thrombosis research·2026

Related Experiment Video

Updated: Oct 23, 2025

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.2K

[Pathophysiology of bleeding].

Sirak Petros1

  • 1Interdisziplinäre Internistische Intensivmedizin, Universitätsklinikum Leipzig, Liebigstr. 20, 04103, Leipzig, Deutschland. sirak.petros@medizin.uni-leipzig.de.

Medizinische Klinik, Intensivmedizin Und Notfallmedizin
|August 17, 2021
PubMed
Summary
This summary is machine-generated.

Understanding bleeding pathophysiology is key to improving patient outcomes. This study highlights the importance of considering both anatomic and hemostatic factors, alongside clinical evaluation, for effective bleeding management.

Keywords:
Blood coagulationBlood coagulation factorsFibrinVascular endotheliumWounds and injuries

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.2K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.0K

Related Experiment Videos

Last Updated: Oct 23, 2025

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.2K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.2K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.0K

Area of Science:

  • Internal Medicine
  • Pathophysiology
  • Hemostasis

Background:

  • Bleeding significantly increases morbidity and mortality.
  • Anatomic causes are more prevalent than hemostatic causes of bleeding.
  • Gastrointestinal bleeding is a primary concern in internal medicine.

Purpose of the Study:

  • To elucidate the complex pathophysiology of bleeding.
  • To emphasize the role of anatomic and hemostatic factors.
  • To guide rational coagulation correction strategies in life-threatening bleeding.

Main Methods:

  • Review of anatomic and hemostatic causes of bleeding.
  • Analysis of secondary homeostatic changes in major bleeding.
  • Evaluation of acquired and hereditary coagulopathies.
  • Discussion of the balance between pro- and anticoagulant pathways.
  • Assessment of limitations in standard laboratory coagulation workup.

Main Results:

  • Anatomic factors are the predominant cause of bleeding.
  • Major bleeding can induce secondary hemostatic changes, exacerbating bleeding and organ dysfunction.
  • Acquired coagulopathies influence bleeding severity more than hereditary disorders.
  • Standard laboratory tests may not fully capture bleeding pathophysiology.
  • The goal of coagulation correction is hemorrhage control, not normalization.

Conclusions:

  • Effective bleeding management requires a comprehensive understanding beyond basic coagulation tests.
  • Clinical evaluation and targeted diagnostics are crucial for successful treatment.
  • Addressing the underlying causes of bleeding is paramount for improving patient survival and reducing complications.