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Clinical Characteristics of H1N1 Influenza A-Associated Mild Encephalopathy with Reversible Splenial Lesion: 4

Xu-Fang Li1, Bin Ai1, Jia-Wei Ye1

  • 1Department of Infectious Disease, Guangzhou Women and Children's Medical Center, Guangzhou, 510000, China.

Current Medical Science
|August 17, 2021
PubMed
Abstract

Insights

Mild encephalopathy with reversible splenial lesion (MERS) in children is linked to H1N1 influenza A. This study details four pediatric cases, showing full recovery with no long-term neurological issues.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • Mild encephalopathy with reversible splenial lesion (MERS) is a recognized neurological condition.
  • MERS is often associated with infections and withdrawal from anti-epileptic drugs.

Purpose of the Study:

  • To describe the clinical characteristics of MERS associated with H1N1 influenza A.
  • To report on four pediatric cases of H1N1 influenza A-associated MERS.

Main Methods:

  • Retrospective analysis of four pediatric patients diagnosed with H1N1 influenza A-associated MERS.
  • Clinical data, viral RNA detection, and neuroimaging findings were reviewed.

Main Results:

  • All patients presented with mild influenza-like symptoms and seizures.
  • Magnetic resonance imaging revealed characteristic splenial lesions in the corpus callosum.
  • All patients recovered fully within two months after treatment with oseltamivir.

Conclusions:

  • H1N1 influenza A is a potential cause of MERS in children.
  • This case series highlights the clinical features and favorable prognosis of H1N1 influenza A-associated MERS.
Keywords:
H1N1childrencorpus callosumencephalopathyinfluenza Amild encephalopathy with reversible splenial lesion

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