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Hydroxysafflor yellow A, a natural compound from Carthamus tinctorius L with good effect of alleviating

Xinyan Xue1, Ying Deng1, Jing Wang1

  • 1State Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|August 17, 2021
PubMed

Insights

Hydroxysafflor yellow A (HSYA) shows promise in treating atherosclerosis by targeting key cellular processes and multiple risk factors. Further clinical trials are needed to confirm its therapeutic potential in humans.

Area of Science:

  • Pharmacology
  • Cardiovascular Research
  • Natural Products

Background:

  • Atherosclerosis is a chronic inflammatory vascular disease leading to heart attack and stroke.
  • Hydroxysafflor yellow A (HSYA), a chalcone glycoside, demonstrates potential in preventing and treating atherosclerosis.

Purpose of the Study:

  • To review the mechanisms of HSYA in treating atherosclerosis.
  • To elucidate HSYA's effects on atherosclerosis risk factors: hyperlipidemia, hypertension, and diabetes mellitus.

Main Methods:

  • Comprehensive literature search in PubMed, Google Scholar, and CNKI.
  • Inclusion of in vitro, in vivo, and clinical studies.
  • Systematic summarization of findings.

Main Results:

  • HSYA suppresses foam cell formation, endothelial dysfunction, vascular smooth muscle cell proliferation, and platelet activation.
  • Mechanisms involve regulating cholesterol transport, oxidative stress, and multiple signaling pathways (e.g., PI3K/Akt/mTOR, NF-κB).
  • HSYA reduces blood lipids, vascular inflammation, and protects pancreatic beta cells.

Conclusions:

  • HSYA demonstrates preventive and therapeutic effects on atherosclerosis and its risk factors through diverse mechanisms.
  • Further clinical investigation is required to establish HSYA's clinical application.
Abstract

Keywords:
AtherosclerosisHydroxysafflor yellow AIndependent risk factorsVascular protection

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