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Colorectal cancer causes alteration of thyroid hormone profile in newly diagnosed patients

Ghazaleh Shimi1, Hamid Zand1, Katayoun Pourvali1

  • 1Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Expert Review of Endocrinology & Metabolism
|August 18, 2021
PubMed
Abstract

Insights

Serum reverse triiodothyronine (rT3) and free triiodothyronine (T3) levels are elevated in early-stage colorectal cancer (CRC) patients. This suggests a potential role for thyroid hormone modulation in CRC development.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Thyroid hormones (THs) signaling is altered in various cancers.
  • Deiodinase type 3, an oncofetal protein, is re-expressed in certain cancer types.
  • Investigating THs metabolites like reverse triiodothyronine (rT3) in cancer is crucial.

Purpose of the Study:

  • To examine serum levels of reverse triiodothyronine (rT3) in newly diagnosed colorectal cancer (CRC) patients.
  • To understand the potential link between deiodinase type 3 activity and CRC.

Main Methods:

  • A cross-sectional study involving 38 confirmed CRC cases.
  • Serum samples analyzed for rT3, total T3, total T4, free T3, free T4, and TSH using ELISA.
  • Enzyme-linked immunosorbent assay (ELISA) employed for precise quantification.

Main Results:

  • Elevated serum levels of rT3 and free T3 were observed in early-stage CRC patients.
  • Normal levels of total T3, total T4, free T4, and TSH were noted.
  • The findings indicate a specific alteration in thyroid hormone metabolism in CRC.

Conclusions:

  • Re-expression of deiodinase type 3 in CRC may explain the elevated rT3 levels.
  • Intracellular thyroid hormone modulation could play a significant role in CRC.
  • Further research is warranted to explore the therapeutic implications of THs modulation in CRC treatment.
Keywords:
Thyroid hormonescolorectal neoplasmsreverse triiodothyroninethyrotropinthyroxinetriiodothyronine

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