Related Experiment Video
Updated: Oct 23, 2025

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
Published on: May 30, 2016
The simpler, the better: tissue vascularization using the body's own resources
Matthias W Laschke1, Michael D Menger1
1Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg/Saar, Germany.
Abstract:
Tissue regeneration is crucially dependent on sufficient vascularization. In regenerative medicine, this can be effectively achieved by autologous vascularization strategies using the body's own resources. These strategies include the administration of blood-derived factor preparations, adipose tissue-based vascularization, and the in situ engineering of vascularized tissue. Due to their simplicity, the translation of these strategies into clinical practice is easier in terms of feasibility, safety requirements, and regulatory hurdles compared with complex and time-consuming procedures involving intensive cell manipulation. Hence, they are close to clinical application or are already being used to successfully treat patients by distinct personalized medicine concepts.
Related Concept Videos
Mechanism of Angiogenesis
Development of Blood Vessels
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Regulation of Angiogenesis and Blood Supply
Overview of the Vascular System
Tissue Renewal without Stem Cells
However, failure of such a system...

