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Published on: September 3, 2016
Effect of BMY-28100, a new cephalosporin, on Staphylococcus aureus nasal carriage
R L Atmar1, M L Allen, J Freiman
1Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.
Abstract:
In order to examine the in vivo activity of BMY-28100, serial quantitative nasal cultures were taken from 52 nasal carriers of Staphylococcus aureus following administration of the antimicrobial. Nasal carriage rates and mean log titers decreased significantly during (days 2-4 and 5-8) and following (days 1-2 and 6-7) treatment. No change in antibiotic sensitivities was noted in follow-up isolates, and the MIC90 remained at 2mcg/ml. BMY-28100 demonstrated good in vivo activity against Staphylococcus aureus.
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