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Updated: Oct 23, 2025

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Published on: June 12, 2021
Spontaneous retroperitoneal haemorrhage secondary to anticoagulation polypharmacy
Mohammed M Uddin1, Tanveer Mir2, Amir Khalil2
1Internal Medicine, Wayne State University, Warren, Michigan, USA mohammed.uddin2@wayne.edu.
Abstract:
Retroperitoneal haemorrhage (RH) is not uncommon in patients with provoking events like trauma. However, spontaneous RH (SRH) is a rare and life-threatening complication described as the development of bleeding into the retroperitoneal cavity, appearing spontaneously and without a preceding history of trauma or other predisposing illness. We are reporting a case of an elderly patient with recurrent deep vein thrombosis who had developed SRH secondary to concurrent use of multiple anticoagulation agents, resulting from poor healthcare follow-up and lack of sufficient medication reconciliation. This article highlights the significance of recognising risk factors for SRH, as well as management strategies through literature review.
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