Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Graft rejection in earthworms: an electron microscopic study.

D S Linthicum, D H Marks, E A Stein

    European Journal of Immunology
    |December 1, 1977
    PubMed
    Summary

    Earthworm graft rejection involves granulocytic coelomocytes (neutrophils) phagocytizing muscle fibers. This invertebrate study shows cell-mediated immunity evolved early in evolutionary history.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cingulate circuits are associated with escalation of heroin use and naloxone-induced increases in heroin self-administration.

    Addiction neuroscience·2023
    Same author

    Nicotine addiction: Translational insights from circuit neuroscience.

    Pharmacology, biochemistry, and behavior·2021
    Same author

    Nicotine dependence (trait) and acute nicotinic stimulation (state) modulate attention but not inhibitory control: converging fMRI evidence from Go-Nogo and Flanker tasks.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2020
    Same author

    Association of cicatricial alopecia with chemical hair straightening.

    The British journal of dermatology·2019
    Same author

    Hair loss among transgender and gender-nonbinary patients: a cross-sectional study.

    The British journal of dermatology·2019
    Same author

    Delayed emergence of methamphetamine's enhanced cardiovascular effects in nonhuman primates during protracted methamphetamine abstinence.

    Drug and alcohol dependence·2016

    Area of Science:

    • Immunology
    • Invertebrate Biology
    • Evolutionary Biology

    Background:

    • Graft rejection is a critical process in transplantation.
    • Understanding the evolutionary origins of immunity provides insights into its fundamental mechanisms.

    Purpose of the Study:

    • To investigate the cellular mechanisms of xenograft rejection in the earthworm Lumbricus terrestris.
    • To determine the role of different coelomocyte types in graft rejection.
    • To explore the evolutionary history of cell-mediated immunity.

    Main Methods:

    • Xenotransplantation of body-wall grafts in Lumbricus terrestris.
    • Observation and analysis of coelomocyte infiltration and activity at the graft site.
    • Comparison of xenograft, autograft, and sham-operated control responses.

    Main Results:

    • Granulocytic coelomocytes (neutrophils) were the primary mediators of xenograft rejection, actively phagocytizing muscle fibers within 1-3 days.
    • Lymphocytic coelomocytes (basophils) played a minor, late role in rejection (days 11-13).
    • Autografts showed limited granulocyte infiltration without complete destruction, and no lymphocytic coelomocytes were observed.

    Conclusions:

    • Graft rejection in Lumbricus terrestris is primarily mediated by granulocytic coelomocytes.
    • Cell-mediated immunity, involving leukocyte-like cells, has ancient evolutionary origins, as evidenced in invertebrates.
    • The study highlights conserved mechanisms of immune response across diverse species.

    Related Experiment Videos