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Pediatric and adult dilated cardiomyopathy are distinguished by distinct biomarker profiles

Melanie R F Gropler1, Steven E Lipshultz2, James D Wilkinson3

  • 1Division of Pediatric Cardiology, Department of Pediatrics, University of Colorado Anschutz Medical center, Aurora, CO, USA.

Pediatric Research
|August 18, 2021
PubMed

Insights

Pediatric dilated cardiomyopathy (DCM) has a unique biomarker profile distinct from adult DCM, suggesting it

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Pediatric Medicine

Background:

  • Dilated cardiomyopathy (DCM) in children and adults are increasingly recognized as distinct diseases.
  • Pediatric cardiologists lack adequate tools for assessing clinical status and prognosis in pediatric DCM.
  • This study hypothesized unique biomarker profiles in pediatric DCM compared to adult DCM.

Purpose of the Study:

  • To compare plasma protein and peptide profiles between pediatric and adult DCM.
  • To identify potential biomarkers for pediatric DCM.
  • To investigate heterogeneity within pediatric DCM.

Main Methods:

  • Utilized a DNA aptamer array (SOMAScan) to measure 1310 plasma proteins and peptides.
  • Analyzed samples from 39 healthy children, 39 pediatric DCM patients, and 40 adult DCM patients.
  • Employed unbiased multidimensionality reduction analysis for biomarker profiling.

Main Results:

  • Distinct plasma biomarker profiles were observed between pediatric and adult DCM patients.
  • Identified 20 plasma peptides and proteins elevated in pediatric DCM compared to controls.
  • Discovered previously unrecognized heterogeneity among pediatric DCM subjects, revealing four subgroups.

Conclusions:

  • Findings support pediatric and adult DCM as distinct disease entities.
  • Highlights the need for pediatric-specific biomarkers for prognostication in DCM.
  • Challenges the view of pediatric DCM as a monolithic condition, emphasizing its heterogeneity.
Abstract

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