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Requirement of a compartmentalization for NADPH oxidizing site and peroxidase-H2O2 in the thyroid iodinating system
N Ait Hammou1, A Virion, D Deme
1INSERM-U. 96, Unité de Recherche sur la Glande Thyroide et la Régulation Hormonale, Bicêtre, France.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|December 1, 1987
Abstract:
In this study, it is shown that NADPH iodination occurs in a thyroid peroxidase-H2O2 system in presence of thyroglobulin, the normal iodination substrate. Previous data suggested that thyroid H2O2 generation is a NADPH-dependent system. Present results support the concept of a compartmentalization of the sites of NADPH oxidation and peroxidasic iodination.