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[Depression as a biopsychosocial problem].
A N Erichev1, A P Kotsubinsky1, S L Kuznetsova1,2
1Bekhterev Saint Petersburg Psychoneurological Research Institute, St. Petersburg, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|August 18, 2021
Summary
This study explores how biological and psychological factors, including genetics and epigenetics, contribute to affective disorders. Psychotherapy is shown to be effective in treatment by influencing both brain and psychological aspects, improving patient quality of life.
Area of Science:
- Psychiatry
- Psychology
- Genetics
Background:
- Affective disorders arise from complex interactions between biological and psychological adaptive mechanisms.
- Genetic vulnerability and epigenetic modifications influenced by psychosocial factors play a crucial role in disease etiology and pathogenesis.
- Psychological factors can disrupt mental functions and individuality, contributing to the psychogenesis of affective disorders at various levels.
Purpose of the Study:
- To examine the interplay of biological, genetic, epigenetic, and psychological factors in affective disorders.
- To substantiate the psychoprophylactic and therapeutic efficacy of psychotherapy in managing affective disorders.
- To advocate for a comprehensive biopsychosocial approach in personalized, person-centered medicine for affective disorders.
Main Methods:
- Review of etiological and pathogenetic mechanisms in affective disorders.
- Analysis of genetic and epigenetic influences on vulnerability.
- Evaluation of psychological factors and their impact on mental functions and individuality.
- Assessment of psychotherapy's effects on biological and psychological parameters, including quality of life.
Main Results:
- Biological and psychological compensatory mechanisms are integral to affective disorder development.
- Psychosocial influences modulate genetic vulnerability through epigenetic mechanisms.
- Psychotherapy demonstrates efficacy by impacting brain parameters and psychological characteristics, enhancing quality of life.
- A biopsychosocial model improves treatment and rehabilitation effectiveness.
Conclusions:
- A comprehensive biopsychosocial approach is essential for understanding and treating the spectrum of affective disorders.
- Personalized, person-centered medicine should integrate phenomenological, psychological, and social adaptation characteristics for optimal outcomes.
- Integrating these factors enhances treatment effectiveness and patient rehabilitation in mental healthcare.
Keywords:
affective disordersbio-psycho-social rehabilitation approachearly stressful eventspsychotherapyMore Related Videos
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