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Evaluation of inflammatory parameters in patients with hepatic hydatid disease
Zhijia Fan1, Yao Hu1, Li Wang1
1Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Insights
Inflammatory markers like platelet distribution width (PDW) and alkaline phosphatase to platelet ratio (APPR) can help evaluate hepatic hydatid disease (HD) and treatment effectiveness. These readily available indicators show significant changes in patients with HD.
Area of Science:
- Hepatology
- Parasitology
- Clinical Biochemistry
Background:
- Hepatic hydatid disease (HD) poses a significant public health challenge.
- The association between inflammatory parameters and hepatic HD has not been previously studied.
- Investigating inflammatory indices may offer new diagnostic and monitoring tools for HD.
Purpose of the Study:
- To evaluate the potential value of inflammatory indices in diagnosing and monitoring hepatic hydatid disease.
- To compare inflammatory marker levels between patients with hepatic HD and healthy controls.
- To assess the changes in inflammatory markers before and after surgical treatment for hepatic HD.
Main Methods:
- Retrospective analysis of 114 patients with hepatic HD from January 2016 to November 2019.
- Collection and analysis of clinical characteristics and laboratory data, including inflammatory parameters.
- Statistical comparison of inflammatory markers between patient and control groups, assessment of predictive value using logistic regression and ROC curves, and pre- vs. post-surgical comparison.
Main Results:
- Patients with hepatic HD showed significantly higher levels of platelet distribution width (PDW), eosinophil percentage (EOS %), neutrophil to lymphocyte ratio (NLR), gamma-glutamyl transpeptidase to platelet ratio (GPR), and alkaline phosphatase to platelet ratio (APPR).
- Lower levels of platelet (PLT) and prognostic nutritional index (PNI) were observed in patients with HD.
- APPR and PNI exhibited more pronounced changes, and PDW and APPR levels significantly decreased after surgery.
Conclusions:
- Specific inflammatory parameters are closely associated with hepatic HD.
- These inflammatory markers can serve as assistant indices for evaluating disease status and treatment effectiveness.
- Future research should integrate these inflammatory markers with histological and radiological findings for comprehensive disease evaluation.
Background:
To the best of our knowledge, the association of inflammatory parameters with hepatic hydatid disease (HD) has not been investigated in a single study. We aimed to evaluate the potential value of inflammatory indices in this disorder.
Methods:
The retrospective study including 114 patients was performed from January 2016 to November 2019. Clinical characteristics and laboratory data for all participants were collected and analysed. The levels of inflammatory parameters were compared in the patient and control group, the predictive value of these inflammatory parameters was assessed by the logistic regression analysis and receiver operating characteristic curve, and differences between pre- and post-surgical operations were compared by pair tests.
Results:
Significantly higher levels of platelet distribution width (PDW), eosinophil percentage (EOS %), neutrophil to lymphocyte ratio (NLR), gamma-glutamyl transpeptidase to platelet ratio (GPR) and alkaline phosphatase to platelet ratio (APPR) and lower levels of platelet (PLT) and prognostic nutritional index (PNI) were observed in patients than in controls. Multivariate analyses showed that hydatid could induce the abnormal levels of these parameters, of which APPR and PNI had more obvious changes as compared to other parameters. The levels of PDW and APPR significantly decreased after surgical treatment.
Conclusions:
Inflammatory parameters closely associated with the hepatic HD could be used in the evaluation of treatment as assistant indexes.KEY MESSAGEHydatid disease (HD) seriously endangers public health and economic development.Inflammatory parameters that are readily available and acceptable in routine clinical practice could be closely associated with HD.Inflammatory parameters could be used in the evaluation of disease development by combing with histological and radiological results in future studies.
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