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Autoimmune Disorders

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Updated: Oct 23, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Published on: December 15, 2011

Autoimmune Progesterone Dermatitis: A Systematic Review.

Zoe M Lipman¹, Angelina Labib, Ashley Vander Does

¹From the Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami, FL.

Dermatitis : Contact, Atopic, Occupational, Drug

|August 18, 2021

Summary

This summary is machine-generated.

Autoimmune progesterone dermatitis (AIPD) presents with varied skin reactions linked to the menstrual cycle. Ovulation suppression and surgery are effective treatments, unlike antihistamines or corticosteroids.

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Area of Science:

Dermatology
Immunology
Gynecology

Background:

Autoimmune progesterone dermatitis (AIPD) is a rare condition causing cyclical skin reactions due to endogenous progesterone.
Clinical presentations vary widely, complicating diagnosis and management for healthcare providers.

Purpose of the Study:

To systematically review clinical features, presentations, and treatment outcomes for AIPD.
To identify effective and ineffective therapeutic strategies for AIPD.

Main Methods:

Systematic review of 112 articles.
Analysis of 132 individual patient cases.

Main Results:

AIPD manifests with diverse dermatological symptoms, including urticaria, erythema multiforme, and anaphylaxis.
Ovulation-suppressing therapies and surgical interventions demonstrated significant treatment success.
Common treatments like antihistamines and systemic corticosteroids showed limited efficacy.

Conclusions:

Effective management of AIPD relies on suppressing ovulation or surgical options.
Further research into AIPD pathogenesis is crucial for developing targeted treatments.