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A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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Predictors associated with sickle cell nephropathy: a systematic review.
Lauana Maurício1, Sara Ribeiro1, Luciana Santos1
1Pontifícia Universidade Católica de Goiás - Goiânia (GO), Brazil.
Revista Da Associacao Medica Brasileira (1992)
|August 18, 2021
Summary
Predictors for chronic kidney disease in sickle cell anemia include lower hemoglobin, older age, and albuminuria. Further research is needed to understand and prevent sickle nephropathy progression.
Area of Science:
- Nephrology
- Hematology
- Genetics
Background:
- Sickle cell anemia impacts over 30 million globally.
- Chronic kidney disease (CKD) affects 40% of sickle cell anemia patients.
- High mortality in sickle nephropathy necessitates predictor identification.
Purpose of the Study:
- Identify predictors for CKD onset in sickle cell anemia.
- Enhance understanding of sickle nephropathy.
- Inform new approaches to managing kidney complications.
Main Methods:
- Systematic review adhering to PRISMA guidelines.
- Included cohort studies on sickle nephropathy predictors.
- Searched literature databases for relevant research.
Main Results:
- Six studies were selected from 321 initial records.
- Lower hemoglobin levels identified as a predictor.
- Increased age and albuminuria are significant predictors of CKD.
Conclusions:
- Key predictors for CKD in sickle cell anemia are low hemoglobin, advanced age, and albuminuria.
- Further research is crucial for understanding and preventing sickle nephropathy.
- Identifying predictors can guide interventions and improve patient outcomes.
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