Related Experiment Video

Updated: Oct 23, 2025

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology
03:33

Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology

Published on: May 23, 2025

323

Fecal calprotectin levels used as a noninvasive method for screening for chronic gastritis in pediatric patients. A

Fatma Demirbaş1, Gönül Çaltepe2, Hasan Abbasguliyev3

  • 1MD. Physician, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.

Sao Paulo Medical Journal = Revista Paulista De Medicina
|August 18, 2021
PubMed

Insights

Fecal calprotectin (FC) levels are elevated in children with chronic gastritis, indicating inflammation. Higher FC levels were observed in active gastritis, especially with H. pylori infection, suggesting FC

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Diagnostics
  • Inflammatory Markers

Background:

  • Gastritis, characterized by gastric mucosa inflammation, is a common cause of dyspeptic symptoms in children.
  • Evaluating inflammatory markers is crucial for understanding pediatric gastritis.
  • Fecal calprotectin (FC) is a known marker for intestinal inflammation.

Purpose of the Study:

  • To investigate the presence of inflammation in children diagnosed with chronic gastritis by assessing fecal calprotectin (FC) levels.
  • To compare FC levels in children with chronic gastritis, inflammatory bowel disease (IBD), and healthy controls.
  • To explore the correlation between FC levels and gastritis activity, including Helicobacter pylori status.

Main Methods:

  • A retrospective descriptive study was conducted in a Pediatric Gastroenterology Department.
  • Fecal calprotectin (FC) levels were analyzed in children with histopathologically confirmed chronic gastritis, IBD patients, and healthy children.
  • Statistical comparisons were performed to evaluate differences in FC levels among the groups and within the chronic gastritis cohort.

Main Results:

  • Children with chronic gastritis exhibited significantly higher FC levels (153.4 μg/g) compared to healthy children (43.8 μg/g).
  • FC levels were highest in the IBD group (589.7 μg/g), followed by chronic gastritis and healthy controls.
  • Elevated FC levels were associated with chronic active gastritis and were significantly higher in H. pylori-positive patients with active gastritis.

Conclusions:

  • The study confirms a significant association between elevated fecal calprotectin (FC) and chronic gastritis in children.
  • Increased FC levels may indicate active gastritis, particularly in cases of H. pylori infection.
  • Further research with larger cohorts is warranted to establish FC as a reliable screening tool for pediatric chronic gastritis.
Abstract

More Related Videos

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

223
Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.505:45

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

13.7K

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
510
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
242