Related Experiment Videos
Cefonicid concentration in lung tissue after intramuscular administration
M Cruciani1, S Savio, E Concia
1Institute of Infectious Diseases, University of Pavia, Italy.
International Journal of Clinical Pharmacology Research
|January 1, 1987
Summary
A single dose of cefonicid, a long-acting cephalosporin antibiotic, achieved effective concentrations in lung tissue and serum for up to 12 hours. This suggests cefonicid may be beneficial for antibiotic prophylaxis in thoracic surgery patients.
Area of Science:
- Pharmacology
- Surgical Oncology
- Infectious Disease
Background:
- Thoracic surgery carries a risk of surgical site infections.
- Effective antibiotic prophylaxis is crucial for patient outcomes.
- Cefonicid is a long-acting cephalosporin with potential prophylactic applications.
Purpose of the Study:
- To evaluate the pharmacokinetic profile of cefonicid in lung tissue and serum.
- To determine the efficacy of a single 1g dose of cefonicid for surgical prophylaxis.
Main Methods:
- A single 1g dose of cefonicid was administered to 16 lung carcinoma patients undergoing thoracic surgery.
- Lung and serum samples were collected at 2, 4, 6, and 12 hours post-injection.
- Antibiotic concentrations were quantified using a microbiological assay.
Main Results:
- Cefonicid demonstrated sustained effective concentrations in both lung tissue and serum throughout the 12-hour sampling period.
- The microbiological assay confirmed the presence of cefonicid at therapeutic levels.
Conclusions:
- A single 1g dose of cefonicid achieves adequate concentrations for potential prophylactic use in thoracic surgery.
- Further investigation into cefonicid's role in preventing surgical site infections in this patient population is warranted.