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Urinary adenosine triphosphate and nitric oxide levels in patients with underactive bladder: a preliminary study
A Krishnan1, G Sharma2, S K Devana3
1Department of General Surgery, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
World Journal of Urology
|August 18, 2021
Summary
Patients with underactive bladder (UAB) have lower urinary adenosine triphosphate (ATP) and higher nitric oxide (NO) levels. The urinary NO/ATP ratio shows promise as a noninvasive diagnostic marker for UAB.
Area of Science:
- Urology
- Biochemistry
- Diagnostic Medicine
Background:
- Animal studies indicate adenosine triphosphate (ATP) stimulates and nitric oxide (NO) inhibits bladder contractility.
- The role of urinary ATP and NO levels in human underactive bladder (UAB) remains uncharacterized.
Purpose of the Study:
- To investigate urinary ATP and NO levels in male patients diagnosed with UAB.
- To compare these levels with those of healthy male volunteers.
Main Methods:
- A prospective case-control study involving 26 male UAB patients (bladder contractility index < 100) and 18 healthy males.
- Measurement of urinary ATP and NO levels.
Main Results:
- Urinary ATP levels were significantly lower in UAB patients compared to controls (p < 0.001).
- Urinary NO levels were significantly higher in UAB patients than in controls (p < 0.001).
- The urinary NO/ATP ratio was significantly higher in UAB patients (p < 0.000) and demonstrated a high diagnostic accuracy (AUC 0.91) for UAB detection.
Conclusions:
- Underactive bladder (UAB) is associated with decreased urinary ATP and increased urinary NO.
- The urinary NO/ATP ratio presents a potential noninvasive biomarker for diagnosing bladder underactivity.
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