Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

773
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
773
Tumor Progression02:07

Tumor Progression

6.7K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.7K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

8.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.4K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

298
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
298
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenotypic Heterogeneity in Crohn's Disease-Associated Intestinal Strictures: An Exploratory Retrospective Cohort Study.

Diagnostics (Basel, Switzerland)·2026
Same author

Precision oncology in primary liver cancer: Bridging the gap between molecular profiling and patient benefit.

Journal of hepatology·2026
Same author

Author Correction: First-line modified FOLFOX plus/minus nivolumab and Ipilimumab or FLOT plus nivolumab in advanced gastroesophageal adenocarcinoma: a phase II multi-cohort IKF-AIO-MOONLIGHT trial.

Nature communications·2026
Same author

The versatile interplay between steatotic liver disease and liver cancer.

Nature reviews. Cancer·2026
Same author

Liver transplantation for refractory portal hypertension syndrome due to intrahepatic arterioportal shunts after treatment of primary hepatic choriocarcinoma: A case report.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19.

Frontiers in immunology·2026
Same journal

[S3 Guideline "Adult soft tissue sarcomas"].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Synopsis-S3 guidelines pancreatic cancer].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Laparoscopic sentinel node navigation surgery in gastric cancer to reduce surgical radicality].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Future concepts for neoadjuvant and adjuvant treatment of (resectable) pancreatic cancer].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[ASCO guidelines for the treatment of stage III NSCLC part 4: indications for adjuvant therapy].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Surgical treatment of pancreatic cancer-What is new?]

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
See all related articles

Related Experiment Video

Updated: Oct 23, 2025

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing
09:24

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing

Published on: June 9, 2016

9.3K

[The molecular tumor board].

Pavlos Missios, Janina Beha, Michael Bitzer

  • 1Abteilung Innere Medizin I, Medizinische Universitätsklinik, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland. Nisar.Malek@med.uni-tuebingen.de.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|August 18, 2021
PubMed
Summary
This summary is machine-generated.

The molecular tumor board integrates experts to interpret complex cancer cases using next-generation sequencing data. This approach improves treatment for previously untreatable patients, demonstrating significant survival benefits.

Keywords:
Medical oncologyMolecular diagnosticsMolecular targeted therapyNext-generation sequencingPersonalized medicine

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.5K
A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
10:13

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

11.3K

Related Experiment Videos

Last Updated: Oct 23, 2025

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing
09:24

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing

Published on: June 9, 2016

9.3K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.5K
A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
10:13

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

11.3K

Area of Science:

  • Oncology
  • Genomics
  • Clinical Pathology

Background:

  • Next-generation sequencing (NGS) has introduced advanced diagnostic tools in oncology.
  • Current clinical workflows require adaptation to effectively process and interpret complex genomic data.
  • There is a need for training existing oncology experts and recruiting new specialists.

Purpose of the Study:

  • To establish a molecular tumor board (MTB) to integrate multidisciplinary expertise.
  • To discuss and assess complex oncological cases informed by molecular diagnostics.
  • To provide recommendations for personalized cancer therapy.

Main Methods:

  • Introduction and implementation of a molecular tumor board.
  • Systematic review and discussion of patient cases with molecular alterations.
  • Therapeutic recommendations based on integrated molecular and clinical data.

Main Results:

  • A steady increase in processed cases since the MTB's establishment 2 years ago.
  • 70% of patients exhibited therapy-relevant molecular alterations.
  • Positive therapeutic responses and improved progression-free/overall survival observed in previously untreatable patients.

Conclusions:

  • Advanced clinical structures, like the MTB, are mandatory with new molecular diagnostics.
  • The MTB plays a crucial role in managing complex oncological cases and guiding therapy.
  • Emerging insights from sequencing data will necessitate the MTB's indispensable role in future cancer treatment.