Related Experiment Video

Updated: Oct 23, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.9K

Global longitudinal strain predicts atrial fibrillation in individuals without hypertension: A Community-based cohort

Flemming Javier Olsen1,2, Sofie Reumert Biering-Sørensen3, Anne Marie Reimer Jensen3,4

  • 1The Copenhagen City Heart Study, Frederiksberg, Denmark. flemming.j.olsen@gmail.com.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
|August 18, 2021
PubMed

Insights

Global longitudinal strain (GLS) predicts atrial fibrillation (AF) in individuals without hypertension. This finding is independent of common risk scores, highlighting GLS as a potential predictor in specific populations.

Area of Science:

  • Cardiology
  • Echocardiography
  • Atrial Fibrillation Research

Background:

  • Global longitudinal strain (GLS) is a sensitive indicator of myocardial dysfunction and atrial reservoir function.
  • Evaluating GLS for predicting atrial fibrillation (AF) in the general population is crucial.

Purpose of the Study:

  • To assess the predictive value of GLS for incident AF in the general population.
  • To investigate the role of hypertension in modifying the relationship between GLS and AF risk.

Main Methods:

  • Analysis of echocardiography data, including speckle tracking, from 1,309 participants in the Copenhagen City Heart Study.
  • AF as the endpoint, identified through national registries.
  • Cox regression analysis with multivariable adjustments for CHADS2 and CHARGE-AF risk factors; abnormal GLS defined as >-18%.

Main Results:

  • Over 15.9 years, 153 participants developed AF.
  • GLS was a univariable predictor of AF but not an independent predictor after adjusting for common risk factors.
  • Hypertension modified the GLS-AF relationship; GLS predicted AF independently in individuals without hypertension, with abnormal GLS associated with a >2-fold increased AF risk.

Conclusions:

  • Global longitudinal strain predicts atrial fibrillation in individuals without hypertension from the general population.
  • GLS provides predictive value for AF independently of established risk scores in this subgroup.
Abstract

Keywords:
Atrial fibrillationEchocardiographySpeckle trackingStrain

More Related Videos

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.6K
High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation09:17

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

Published on: July 29, 2011

15.0K

Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.8K
Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
293
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
111
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
189
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
5.6K
Assessment of blood pressure in brachial artery(two-step method)01:23

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
1.0K