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Updated: Oct 23, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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Pathologic myopia and severe pathologic myopia: correlation with axial length.

Ignacio Flores-Moreno1, Mariluz Puertas2, Elena Almazán-Alonso2

  • 1Puerta de Hierro University Hospital, C/Manuel de Falla 1, 28222, Majadahonda (Madrid), Spain. floresmorenoignacio@gmail.com.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|August 18, 2021
PubMed
Summary
This summary is machine-generated.

Axial length (AL) is key in high myopia. This study establishes AL cut-off values of 28 mm and 29.5 mm to differentiate pathologic myopia (PM) from severe PM, aiding clinical management.

Keywords:
ATN classificationHigh myopiaPathologic myopiaSevere pathologic myopia

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • High myopia is associated with significant visual impairment.
  • The ATN grading system categorizes severity based on atrophic (A), tractional (T), and neovascular (N) changes.
  • Distinguishing between pathologic myopia (PM) and severe PM is crucial for patient management.

Purpose of the Study:

  • Correlate axial length (AL), age, and visual acuity in high myopic patients using the ATN system.
  • Determine AL cut-off values to differentiate PM from severe PM.
  • Identify clinical distinctions between PM and severe PM.

Main Methods:

  • Cross-sectional, non-interventional study design.
  • Comprehensive ophthalmologic examinations including multimodal imaging.
  • ATN grading and classification of eyes into PM or severe PM categories.

Main Results:

  • Significant differences in ATN components, age, BCVA, and AL between PM and severe PM groups (p < 0.05).
  • AL showed linear correlations with A, T, and N components (r = 0.53, 0.24, 0.20; p < 0.01).
  • Optimal AL cut-off values: 28 mm for PM (AUC 0.813) and 29.5 mm for severe PM (AUC 0.760).

Conclusions:

  • Axial length is the primary variable linked to myopic maculopathy.
  • Objective AL cut-off points (28 mm and 29.5 mm) are necessary to distinguish PM from severe PM.
  • These AL values are vital for appropriate follow-up, ophthalmic management, and treatment strategies.