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Updated: Oct 23, 2025
Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Published on: March 21, 2021
Computed Tomography-Determined Body Composition Abnormalities Usefully Predict Long-term Mortality in Patients With
Young Seo Cho1, Ha Young Lee2, Jae Yoon Jeong
1From the Department of Radiology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri.
Objective:
We evaluated the prognostic impacts of body composition components measured by computed tomography (CT) in patients with liver cirrhosis.
Methods:
A total of 160 cirrhotic patients who underwent CT and hepatic venous pressure gradient measurements were retrospectively enrolled. Cross-sectional areas of skeletal muscle, visceral and subcutaneous fat, and mean CT attenuation of trabecular bone of the fourth lumbar vertebral level (L4HU) were measured.
Results:
Multivariate analysis showed model for end-stage liver disease score [hazard ratio (HR), 1.086; 95% confidence interval (CI), 1.020-1.156; P = 0.010], hepatic venous pressure gradient (HR, 1.076; 95% CI, 1.021-1.135; P = 0.006), sarcopenia (HR, 1.890; 95% CI, 1.032-3.462; P = 0.039), and L4HU (HR, 1.960 for L4HU <145 Hounsfield units; 95% CI, 1.094-3.512; P = 0.024) were independently associated with long-term mortality. In patients with decompensated cirrhosis, subcutaneous adipose tissue index was the only independent predictor (HR, 0.984; 95% CI, 0.969-0.999; P = 0.039).
Conclusion:
Body composition abnormalities determined by CT are associated with long-term prognosis in cirrhotic patients.
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