Bacteremic infections in granulopenic patients in Israel
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Y Siegman-Igra1, D Schwartz, I Gonen
1Infectious Disease Unit, Rokach (Hadassah) Hospital, Tel Aviv, Israel.
Abstract:
Forty-four bacteremic, granulopenic patients hospitalized during a 4-year period (between 1980 and 1983) in the Tel Aviv Medical Center are reviewed. Fifty-four organisms were recovered from the 44 patients, including 17 strains in 8 patients (18%) in mixed infections. Eighty-three percent of the organisms were gram-negative and 17% gram-positive. The most common organism was Pseudomonas aeruginosa. Seventy percent of the infections were hospital acquired, and the most common focus of infection was the urinary tract. The most resistant strains of microorganisms grew in hospital-acquired infections and in people who were already receiving antimicrobials. These findings differ somewhat from previously published data.
Insights
This study reviewed 44 bacteremic, granulopenic patients, finding Pseudomonas aeruginosa most common. Hospital-acquired infections, often urinary tract related, showed increased antimicrobial resistance.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Hospital Epidemiology
Background:
- Bacteremia and granulopenia in hospitalized patients present significant clinical challenges.
- Understanding causative organisms and infection patterns is crucial for effective treatment.
- Previous data on antimicrobial resistance in these patient groups requires updated insights.
Purpose of the Study:
- To analyze the spectrum of microorganisms causing bacteremia in granulopenic patients.
- To identify the common sources and types of infections in this vulnerable population.
- To assess antimicrobial resistance patterns, particularly in hospital-acquired infections.
Main Methods:
- Retrospective review of 44 bacteremic, granulopenic patients over a 4-year period (1980-1983).
- Identification and characterization of 54 recovered bacterial organisms.
- Analysis of infection acquisition (hospital-acquired vs. community-acquired) and primary focus.
Main Results:
- Gram-negative bacteria predominated (83%), with Pseudomonas aeruginosa being the most frequent isolate.
- Hospital-acquired infections accounted for 70% of cases, with the urinary tract as the most common site.
- Increased antimicrobial resistance was observed in hospital-acquired infections and in patients already on antimicrobials.
Conclusions:
- Pseudomonas aeruginosa is a key pathogen in bacteremic granulopenic patients.
- Urinary tract infections are a common focus, especially in hospital-acquired settings.
- Antimicrobial resistance is a growing concern, particularly in healthcare-associated infections and among patients receiving prior antimicrobial therapy.