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Hemoperfusion with CytoSorb® in Critically Ill COVID-19 Patients
Jin-Yu Peng1, Lu Li2, Xu Zhao3
1School of Medicine, Class 2017, Nanchang University, Nanchang, China.
Blood Purification
|August 18, 2021
Summary
CytoSorb hemoperfusion in critically ill COVID-19 patients reduced IL-6 and improved oxygenation and lactate levels. However, further randomized trials are needed to confirm these findings.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Biomedical Engineering
Background:
- Critically ill COVID-19 patients often experience systemic inflammation.
- Cytokine reduction via hemadsorption is a potential therapeutic strategy.
- The efficacy of CytoSorb hemoperfusion in this population was previously unestablished.
Purpose of the Study:
- To evaluate the effectiveness of CytoSorb hemoperfusion as a rescue therapy for critically ill COVID-19 patients.
- To assess changes in IL-6 levels and organ function parameters post-treatment.
Main Methods:
- A case series of 10 critically ill COVID-19 patients receiving CytoSorb hemoperfusion was observed.
- Data on demographics, laboratory results, and clinical status were collected.
- IL-6 levels and organ function parameters (e.g., PaO2/FiO2, lactate) were compared before and after treatment.
Main Results:
- CytoSorb hemoperfusion significantly decreased Interleukin-6 (IL-6) levels (p = 0.005).
- Significant improvements were observed in oxygenation (PaO2/FiO2, p = 0.04) and lactate levels (p = 0.009).
- Hemodynamics showed a slight improvement, while albumin levels decreased mildly.
Conclusions:
- CytoSorb hemoperfusion in critically ill COVID-19 patients was associated with reduced IL-6 and improved oxygenation.
- The observed effects require confirmation through large-scale randomized clinical trials due to the lack of control groups.
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