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Updated: Oct 23, 2025
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
Rapid intraoperative perfusion assessment of parathyroid adenomas with ICG using a wide-field portable hand-held
Jared Matson1, Thinzar M Lwin2, Michael Bouvet3
1Department of Surgery, UC San Diego, San Diego, CA, USA.
Background:
Fluorescence angiography (FA) using indocyanine green dye (ICG) has recently been introduced for real-time identification of parathyroid adenomas. However, time to peak fluorescence has not yet been critically evaluated.
Methods:
This was a retrospective review of parathyroidectomies with ICG FA over a one-year period.
Results:
There were 66 patients with average age of 64 years. The average time to initial fluorescence was 26.7 s and to peak fluorescence was 38.0 s. The time to saline flush administration significantly correlated with times to initial and peak fluorescence (p < .0001). The rate of in-situ fluorescence was 97%. The rates of suspected adenoma detection were 69% for sestamibi scan, 71% for ultrasound, and 96% for CT scan. Imaging was discordant in 13 cases (20%), with the adenoma located on the opposite side of the neck in 4 cases.
Conclusions:
ICG FA is a rapid and effective adjunct for the intraoperative identification of parathyroid adenomas.
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