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Miconazole sorption to intravenous infusion sets
A G McGookin1, J S Millership, E M Scott
1Department of Pharmacy, Queen's University of Belfast, Medical Biology Centre, Northern Ireland.
Journal of Clinical Pharmacy and Therapeutics
|December 1, 1987
Summary
Miconazole antifungal drug sorption to infusion bag plastics is low. This study found minimal drug loss, ensuring miconazole retains clinical efficacy during intravenous administration.
Area of Science:
- Pharmaceutical Science
- Drug Delivery Systems
- Materials Science
Background:
- Miconazole is a widely used antifungal medication administered intravenously.
- The interaction between drugs and medical plastics can affect drug concentration and efficacy.
- Infusion bags and administration sets are common medical devices for drug delivery.
Purpose of the Study:
- To investigate the extent of miconazole sorption onto common plastics used in medical devices.
- To determine if miconazole sorption impacts its clinical effectiveness.
Main Methods:
- High-performance liquid chromatography (HPLC) was employed to quantify miconazole concentrations.
- Experiments simulated the conditions of intravenous drug administration.
Main Results:
- Sorption of miconazole onto the investigated plastics was found to be low.
- The measured concentrations of miconazole remained within clinically acceptable ranges.
Conclusions:
- The sorption of miconazole to infusion bags and intravenous administration sets is minimal.
- The low sorption suggests no significant compromise in miconazole's clinical efficacy.