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Related Experiment Videos

Experimental diabetes in the rat: alterations in the vesical function.

M Paro1, M Prosdocimi

  • 1Fidia Research Laboratories, Abano Terme, Italy.

Journal of the Autonomic Nervous System
|November 1, 1987
PubMed
Summary

Alloxan-induced diabetes in rats impairs bladder function, increasing the threshold volume for the micturition reflex and causing irregular contractions. Ganglioside treatment improved these vesical dysfunctions in diabetic rats.

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Area of Science:

  • Urology
  • Endocrinology
  • Neuroscience

Background:

  • Alloxan-induced diabetes in rats is a model for studying diabetes-related complications.
  • Vesical function is regulated by the autonomic nervous system, with parasympathetic stimulation inducing contractions and sympathetic stimulation inhibiting them.
  • Experimental diabetes can lead to autonomic nervous system dysfunction, potentially affecting bladder control.

Purpose of the Study:

  • To investigate the effects of experimental diabetes on vesical function in rats.
  • To determine if ganglioside administration can ameliorate diabetes-induced bladder dysfunction.

Main Methods:

  • Male Sprague-Dawley rats were made diabetic using alloxan and compared to control groups.
  • Bladder function was assessed by recording rhythmic contractions evoked by controlled bladder distension (micturition reflex).

Related Experiment Videos

  • Diabetic rats received bovine brain gangliosides or saline, and bladder enlargement, threshold volume, and contraction rate were analyzed.

    • Main Results:

    • Diabetic rats exhibited increased threshold volumes for the micturition reflex (1.7 ml at 3 months, 3.2 ml at 6 months) compared to controls (0.5-1 ml).
    • Bladder contractions became more irregular with longer diabetes duration, associated with bladder enlargement.
    • Ganglioside treatment significantly reduced bladder enlargement, lowered the micturition reflex threshold volume, and improved contraction regularity.

    Conclusions:

    • Experimental diabetes causes significant functional vesical dysfunction in rats, characterized by impaired micturition reflex and bladder enlargement.
    • Ganglioside administration shows therapeutic potential in mitigating these diabetes-induced bladder abnormalities.
    • Alterations in the autonomic nervous system likely contribute to vesical dysfunction observed in experimental diabetes.