Related Experiment Video
Updated: Oct 23, 2025

07:13
A Simple and Reproducible Method to Prepare Membrane Samples from Freshly Isolated Rat Brain Microvessels
Published on: May 7, 2018
10.4K
Correction to: Polyphenols journey through blood-brain barrier towards neuronal protection
I Figueira1,2, G Garcia1,2, R C Pimpão1,2
1Instituto de Tecnologia Quı́mica e Biológica-António Xavier, Universidade Nova de Lisboa, Av. da República, EAN, 2781-901, Oeiras, Portugal.
Scientific Reports
|August 19, 2021
Abstract
No abstract available in PubMed .
Related Concept Videos
The Blood-brain Barrier
50.0K
Overview
50.0K
Physiological Barriers
4.6K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
4.6K
Factors Affecting Drug Distribution: Physiological Barriers
436
Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
436

