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[Anticholinergics and urination disorders].

S Conquy1, L Boccon-Gibod, J P Boiteux

  • 1Service d'Urologie, Hôpital Cochin, Paris.

Journal D'Urologie
|January 1, 1987
PubMed
Summary
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Anticholinergic drugs effectively treat urge incontinence and frequency in patients with detrusor instability when an anticholinergic test is positive. Oral treatment showed improvement in these specific cases.

Area of Science:

  • Urology
  • Pharmacology

Background:

  • Urge incontinence and micturition frequency are common lower urinary tract symptoms.
  • Detrusor instability is a frequent urodynamic finding in these patients.
  • The efficacy of anticholinergic drugs is often evaluated through specific tests.

Purpose of the Study:

  • To assess the utility of an anticholinergic test in predicting treatment response.
  • To evaluate the effectiveness of oral anticholinergic medication in patients with urge incontinence and frequency.

Main Methods:

  • Urodynamic assessment including an anticholinergic test was performed on 145 patients.
  • Patients were categorized based on urodynamic findings and test results.
  • Treatment response to oral anticholinergic medication was observed.

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Main Results:

  • Eighty percent of patients exhibited detrusor instability.
  • The anticholinergic test was positive in half of the patients with detrusor instability.
  • Oral anticholinergic treatment improved symptoms in patients with positive tests and detrusor instability.

Conclusions:

  • Anticholinergic drugs are beneficial for urge incontinence and frequency when detrusor instability is present and the anticholinergic test is positive.
  • The anticholinergic test can help identify patients likely to respond to oral anticholinergic therapy.
  • Anticholinergic medications may not be effective in patients without detrusor instability or with negative test results.