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Updated: Oct 23, 2025
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
Unresectable hepatocellular carcinoma treatment with doxorubicin-eluting polyethylene glycol microspheres: a
Gerardo Tovar-Felice1, Andrés García-Gámez1, Virgilio Benito-Santamaría1
1Germans Trias I Pujol (Can Ruti) University Hospital, Carretera de Canyet, Badalona, 08916, Spain.
Background:
Transarterial chemoembolization (TACE) is indicated for unresectable hepatocellular carcinoma.
Methods:
This was a retrospective study of 50 hepatocellular carcinoma patients treated with TACE using doxorubicin-loaded LifePearl™ to investigate the safety and efficacy of TACE.
Results:
There was no 30-day mortality, and limited adverse events were reported. At best tumor response, complete response and disease control were 58% and 94%, respectively, with a median of 4.5 months of follow-up. Median overall survival was 33.8 months. Patients with Barcelona Clinic Liver Cancer stage 0 and stage A at best tumor response showed a higher complete response rate (83%) than patients with Barcelona Clinic Liver Cancer stage B (complete response: 50%; p = 0.0414).
Conclusion:
Doxorubicin-loaded LifePearl™ TACE might be an effective treatment, with a good safety profile, for patients with early/intermediate-stage hepatocellular carcinoma. Further prospective data, especially with a small cohort of selected patients, are required to confirm these results.
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