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Related Experiment Video

Updated: Oct 23, 2025

Micropatterning and Assembly of 3D Microvessels
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Prevascularized Micro-/Nano-Sized Spheroid/Bead Aggregates for Vascular Tissue Engineering.

Maedeh Rahimnejad1,2, Narges Nasrollahi Boroujeni3, Sepideh Jahangiri2,4

  • 1Biomedical Engineering Institute, School of Medicine, Université de Montréal, Montreal, Canada.

Nano-Micro Letters
|August 19, 2021
PubMed
Summary

Developing new vascular tissue engineering strategies is key for regenerative medicine. This study reviews advanced biofabrication methods for creating microvascular networks using nano- and micro-sized aggregates and beads.

Keywords:
MicrospheresNano-/micro-sized aggregatesVascular tissue engineering

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Last Updated: Oct 23, 2025

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Published on: September 9, 2016

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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device
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Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering
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Area of Science:

  • Regenerative Medicine
  • Vascular Tissue Engineering
  • Biotechnology

Background:

  • Efficient microvascularization is crucial for regenerative medicine applications.
  • Current strategies for creating functional microvascular networks are limited.
  • Capillaries, the smallest blood vessels, form dense networks essential for tissue function.

Purpose of the Study:

  • To review advanced biofabrication methods for microvascular engineering.
  • To highlight recent advancements in creating prevascularized nano- and micro-sized aggregates and spheres.
  • To discuss strategies for mimicking the body's natural microvascular networks.

Main Methods:

  • Extrusion-based bioprinting
  • Droplet-based bioprinting
  • Kenzan techniques
  • Biogripper approaches

Main Results:

  • Discussion of novel biofabrication techniques for vascular tissue engineering.
  • Emphasis on the development of prevascular nano- and micro-sized aggregates.
  • Exploration of microsphere and microbead applications in creating microvascular beds.

Conclusions:

  • Advanced biofabrication methods offer promising routes for microvascular engineering.
  • Nano- and micro-sized aggregates and beads are key components for building primitive microvascular beds.
  • Further research in these areas is vital for advancing regenerative medicine.