Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heredity-environment interaction and schizophrenia.

F Schulsinger1, J Parnas, S Mednick

  • 1Department of Psychiatry, Kommunehospitalet, Copenhagen, Denmark.

Journal of Psychiatric Research
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The neurophenomenology of early psychosis: An integrative empirical study.

Consciousness and cognition·2019
Same author

L'Encephale·2019
Same author

Exploring social cognition in schizophrenia.

European archives of psychiatry and clinical neuroscience·2016
Same author

Temporal persistence of anomalous self-experience: A 5years follow-up.

Schizophrenia research·2016
Same author

Pathologies of imagination in schizophrenia spectrum disorders.

Acta psychiatrica Scandinavica·2014
Same author

[Epizootic diseases in Poland with special reference to zoonosis].

Postepy higieny i medycyny doswiadczalnej·2014
Same journal

Cannabis use patterns and psychotic-like experiences: a cross-sectional study of heavy users, occasional users, and non-users.

Journal of psychiatric research·2026
Same journal

Psychiatric or psychological treatment of depression in older adults and subsequent risk of dementia: Health and Retirement Study2012-2020.

Journal of psychiatric research·2026
Same journal

Analysis of the association between outdoor artificial light exposure and depressive symptoms in patients with different subtypes of depression.

Journal of psychiatric research·2026
Same journal

Linking socioeconomic context to functional brain network abnormalities and clinical severity in children with Tourette syndrome.

Journal of psychiatric research·2026
Same journal

Development and validation of the 5-item intimate partner violence scale (IPVS-5): Psychometric properties in a large-scale Chinese study.

Journal of psychiatric research·2026
Same journal

Sleep health profiles of young adult college students: A latent profile analysis.

Journal of psychiatric research·2026
See all related articles

Longitudinal studies of high-risk children reveal environmental factors like birth complications contribute to schizophrenia. Schizotypal personality disorder, potentially genetic, may precede schizophrenia.

Area of Science:

  • Psychiatry
  • Developmental Psychology
  • Genetics

Background:

  • Longitudinal studies of at-risk populations are crucial for understanding hereditary and environmental influences on mental health.
  • Schizophrenia research often involves examining risk factors from early life.
  • The Mednick and Schulsinger (1962) study provides valuable data on high-risk children.

Purpose of the Study:

  • To investigate the roles of hereditary and environmental factors in the development of schizophrenia.
  • To analyze the impact of pregnancy/birth complications and early institutional rearing on schizophrenia development in at-risk children.
  • To explore the relationship between schizotypal personality disorder and schizophrenia.

Main Methods:

  • Utilized data from a longitudinal prospective study of children at high-risk for schizophrenia.

Related Experiment Videos

  • Compared outcomes in high-risk children with low-risk controls.
  • Examined correlations between perinatal complications, early rearing environments, and psychiatric outcomes.

    • Main Results:

    • Pregnancy and birth complications, along with institutional rearing, were associated with schizophrenia in high-risk children, but not in controls.
    • Children with schizotypal personality disorder showed minimal exposure to perinatal complications.
    • Schizophrenia may represent a more severe manifestation of genetically influenced schizotypal personality disorder.

    Conclusions:

    • Environmental factors significantly contribute to schizophrenia development in genetically predisposed individuals.
    • Schizotypal personality disorder may be a genetically transmitted precursor to schizophrenia.
    • Early life experiences interact with genetic vulnerability to influence schizophrenia risk.