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Updated: Oct 23, 2025

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
The Relationship Between Insulin Use And Increased Mortality In Patients With COVID-19 And Diabetes: A Meta-Analysis
Wanteng Wang1, Yu Sun1, Shuai Wang1
1The Affiliated Hospital Of Qingdao University, Qingdao University, Qingdao, China.
Purpose:
The purpose of this study is to review observational studies on the effect of insulin use and mortality in patients with COVID-19 and diabetes.
Methods:
A systematic literature search was performed using the PubMed, Medline, EMBASE, and Cochrane Library databases. The meta-analysis was performed using a random effects model, and I2 was applied to evaluate heterogeneity. Sensitivity and subgroup analyses were also performed.
Results:
Overall, 1,338 patients over six studies were ultimately included. Insulin use was related to a higher risk of death in diabetic patients with COVID-19 compared to those who did not use insulin (odds ratio: 2.59, 95% confidence interval: 1.66-4.05; P < .0001; I2: 57%).
Conclusions:
This meta-analysis revealed a correlation between insulin usage and increased mortality in diabetic patients with COVID-19. These results showed that insulin requirement in patients with COVID-19 and diabetes might indicate a poor prognosis.
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