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Frailty Assessment in an Aging Mouse Model
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Development and Validation of a Multidimensional Frailty Scale for Clinical Geriatric Assessment.

J Shin1, M Kim, J Choi

  • 1Jaekyung Choi, Department of Family Medicine, Research Institute of Medical Science, Konkuk University School of Medicine, Konkuk University Medical Center, 120-1, Neungdong-ro, Gwangjin-gu, Seoul, 05030, South Korea, Tel: +82-2-2030-7683; Fax: +82-2-2030-7748;

The Journal of Nutrition, Health & Aging
|August 19, 2021
PubMed
Summary

The Korean Frailty Scale (KFS) is a new tool assessing physical, psychological, and social frailty in older adults. It effectively predicts adverse health outcomes like falls and mortality in community-dwelling populations.

Keywords:
Frail elderlygeriatric assessmentvalidation studies

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Area of Science:

  • Gerontology
  • Clinical Geriatrics
  • Public Health

Background:

  • Frailty is a significant geriatric syndrome associated with adverse health outcomes.
  • Existing frailty assessment tools may not capture the multidimensional nature of frailty.
  • There is a need for a validated, multidimensional frailty assessment tool for clinical settings.

Purpose of the Study:

  • To develop a multidimensional frailty assessment tool, the Korean Frailty Scale (KFS).
  • To examine the psychometric properties and predictive validity of the KFS in a clinical setting.
  • To assess the KFS's ability to predict adverse health outcomes in older adults.

Main Methods:

  • Developed the KFS through literature review and expert consensus, comprising six questions.
  • Validated psychometric properties in 2,923 community-dwelling older adults using the Korean Frailty and Aging Cohort Survey.
  • Utilized Receiver Operator Characteristic (ROC) analyses for cutoff scores and assessed predictive validity for mortality, hospitalization, falls, and disability (ADL/IADL).

Main Results:

  • The KFS effectively categorized participants into frail (21.1%), pre-frail (50.2%), and robust (28.7%) groups.
  • The KFS demonstrated sufficient sensitivity (88.3%), specificity (91.6%), and AUC (0.730) for the frail group.
  • The frail group exhibited significantly increased risks of falling (RR: 1.810), mortality (HR: 6.596), and IADL decline (RR: 1.638).

Conclusions:

  • The Korean Frailty Scale (KFS) is a valid and reliable multidimensional frailty assessment tool.
  • The KFS is effective for clinical geriatric assessment in Korean community-dwelling older adults.
  • The KFS accurately predicts adverse health outcomes, aiding in early intervention and management.