Experience of transcatheter device closure of atrial septal defect in a tertiary care institute
Related Experiment Video
Updated: Oct 23, 2025
Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Muhammad Younas1, Ahsan Beg2, Tauseef Asma2
1Department of Paediatric Cardiology, Chaudhry Pervaiz Elahi Institute of Cardiology, Multan.
Insights
Transcatheter device closure is a safe and effective treatment for secundum atrial septal defects in both children and adults. This study demonstrated a high success rate with minimal complications in 75 patients.
Area of Science:
- Cardiology
- Interventional Cardiology
- Paediatric Cardiology
Background:
- Secundum atrial septal defect (ASD) is a common congenital heart condition.
- Transcatheter device closure offers a minimally invasive alternative to surgical repair.
- Institutional experience with this procedure in a diverse age group is valuable.
Purpose of the Study:
- To evaluate the institutional experience with transcatheter device closure of secundum ASD.
- To assess the safety and efficacy of this procedure in children and adults.
- To report outcomes in patients with moderate to large ASDs.
Main Methods:
- A descriptive cross-sectional study of 75 patients with moderate to large secundum ASD.
- Procedures performed under general anaesthesia with trans-oesophageal echo guidance.
- Data collected on patient demographics, defect size, device type, and procedural outcomes.
Main Results:
- The study included 75 patients (mean age 25 years; range 4-54 years) with ASDs (mean defect size 20.38mm).
- The Amplatzer septal occluder was the most common device used (80%).
- Overall procedural success was 97.3%, with no procedure-related mortality; transient arrhythmias and pericardial effusion were the main complications.
Conclusions:
- Transcatheter device closure is a safe and effective treatment for moderate to large secundum ASD in children and adults.
- The procedure has a high success rate and a low complication profile.
- This approach provides a viable alternative to surgical intervention.
Objective:
To share institutional experience of transcatheter device closure of secundum atrial septal defect in children and adults.
Methods:
The descriptive cross-sectional study was conducted at the Department of Paediatric Cardiology, Institute of Cardiology, Multan, Pakistan, from February 2011 to September 2019, and comprised patients with moderate to large secundum atrial septal defect without severe pulmonary hypertension. All procedures were performed under general anaesthesia and trans-oesophageal echo guidance. Success and safety of procedure were evaluated. Data was analysed using SPSS 16.
Results:
Of the 75 patients, 26(34.6%) were males and 49(65.3%) were females. The overall mean age was 25±1.53 years (range: 4 -54 years). Mean defect was 20.38±0.58mm (range: 9-32mm). Large defects >25mm were 17(22.7%). Significant pulmonary stenosis was observed in 3(4%) patients and valvuloplasty was performed. Device size was selected on the basis of trans-oesophageal echo measurement +4-5mm. Balloon sizing was performed in only 3(4%) patients. Amplatzer septal occluder was used in 60(80%) patients. Balloon-assisted technique was used in 9(12%) patients. All the procedures were successful except 2(2.7%) where device was embolised and retrieved by surgery. Transient arrhythmias were observed in 6(8%) patients and small pericardial effusion in 1(1.3%) patient who was managed conservatively. There was no procedure-related mortality.
Conclusion:
Transcatheter closure of moderate to large secundum atrial septal defect in children and adults was found to be a safe procedure.
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