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Autoimmune thyroid disease in children with diabetes and adolescents: A single center study from south Punjab
Waqas Imran Khan1, Erum Afzal2, Sajjad Hussain3
1Department of Paediatric Endocrinology, The Children Hospital and The Institute of Child Health, Multan, Pakistan.
Objective:
To evaluate the prevalence of autoimmune thyroid disease in children with diabetes.
Methods:
The descriptive cross-sectional study was conducted from January to December 2019 at the Children Hospital and the Institute of Child Health, Multan, Pakistan, and comprised paediatric type 1 diabetes mellitus patients of both genders. Blood samples were obtained for detailed testing of thyroid functions tests. Data was analysed using SPSS 20.
Results:
Of the 161 paediatric subjects, 83(51.6%) were boys. The overall mean age was 9.7±4.3 years. Thyroid peroxidase antibody was positive in 34(21.1%) patients and thyroglobulin antibody in 27(16.7%). Both antibodies were positive in 17(10.5%) patients. Six (3.7%) patients had evidence of subclinical hypothyroidism, 8(4.9%) had overt hypothyroidism and 1(0.62%) had hyperthyroidism.
Conclusions:
The prevalence of autoimmune thyroid disease among children and adolescents with type 1 diabetes mellitus was 21%, with hypothyroidism being more prevalent compared to hyperthyroidism.
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