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Updated: Oct 23, 2025

A Microfluidic Technique to Probe Cell Deformability
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Microfluidic Devices as Process Development Tools for Cellular Therapy Manufacturing.

Jorge Aranda Hernandez1, Christopher Heuer2, Janina Bahnemann2

  • 1Biochemical Engineering Department, University College London (UCL), London, UK.

Advances in Biochemical Engineering/Biotechnology
|August 19, 2021
PubMed
Summary
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Microfluidic devices offer a promising solution for personalized cell therapy manufacturing, addressing challenges of current labor-intensive methods. These closed, automated systems enhance control and reproducibility in cell processing for various therapies.

Area of Science:

  • Biotechnology
  • Cellular Therapy Manufacturing
  • Microfluidics

Background:

  • Cellular therapies are revolutionizing biomanufacturing, especially autologous treatments.
  • Current small-scale cell therapy production is labor-intensive with open-handling steps.
  • Good Manufacturing Practice (GMP)-in-a-box systems offer automation but are still developing.

Purpose of the Study:

  • To explore microfluidic devices as a solution for small-scale cell therapy manufacturing.
  • To highlight advances in microfluidics for key cell manufacturing process steps.
  • To review the state-of-the-art in microfluidic cell culture for stem cell and immunotherapy applications.

Main Methods:

  • Review of recent advances in microfluidic devices for cell manufacturing.
Keywords:
BiomanufacturingCAR-TCell and gene therapyCell cultureCell manufacturingGMP-in-a-boxImmunotherapyMedical biotechnologyMicrofluidicsScale-downScale-upStem cellsTranslation

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  • Analysis of microfluidic systems for both adherent and suspension cell cultures.
  • Focus on unit operations critical for stem cell therapies and immunotherapies.

    • Main Results:

    • Microfluidic devices share key features with GMP-in-a-box systems: closed, automated fluid handling, and integrated sensors.
    • Microfluidics enables precise spatiotemporal control over the cellular microenvironment.
    • Disposable microfluidic devices offer a scalable and reproducible approach to cell processing.

    Conclusions:

    • Microfluidics presents a viable alternative to overcome limitations in current cell therapy manufacturing.
    • These devices hold potential for improving reproducibility and control in personalized medicine.
    • Further development of microfluidic platforms can significantly advance cell-based immunotherapy and stem cell therapy production.