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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
Published on: November 4, 2015
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Chronic Thromboembolic Pulmonary Hypertension: the Bench
George A Alba1, Deepak Atri2, Sriranjani Darbha3
1Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA, USA.
Current Cardiology Reports
|August 19, 2021
Summary
Chronic thromboembolic pulmonary hypertension (CTEPH) arises from unresolved pulmonary embolism (PE) clots. Understanding CTEPH pathobiology is crucial for developing effective treatments.
Area of Science:
- Pulmonary Hypertension Research
- Thrombosis and Hemostasis
Background:
- Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare sequela of acute pulmonary embolism (PE).
- Pathological thrombus resolution leads to fibrotic obstruction in pulmonary arteries.
Purpose of the Study:
- To review the current understanding of CTEPH pathobiology.
- To highlight knowledge gaps hindering the development of new CTEPH therapies.
Main Methods:
- Review of human sample studies.
- Analysis of animal models of CTEPH.
- Examination of research on platelet biology and inflammation in CTEPH.
Main Results:
- CTEPH involves organized, fibrotic thrombi with endothelial cells, myofibroblasts, and immune cells.
- Associated vasculopathy resembles pulmonary arterial hypertension.
- Platelet biology and inflammation play key roles in thrombus organization.
Conclusions:
- Current research models have limitations in fully recapitulating CTEPH.
- Further insights into CTEPH pathobiology are essential for therapeutic advancements.
- Bridging the gap between basic research and clinical application is critical for new CTEPH treatments.
Keywords:
Chronic thromboembolic pulmonary hypertensionInflammationMyofibroblastPlateletPulmonary embolismPulmonary hypertensionMore Related Videos
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