Related Experiment Video

Updated: Oct 23, 2025

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
07:36

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

289

A Case of Topical Ofloxacin-Induced Otomycosis and Literature Review

Mohamed Mahdi Alshahni1,2, Rima Zakzuk Alshahni3, Ryuichi Fujisaki4

  • 1Laboratory of Medical Mycology and Space Environmental Medicine, School of Medicine, Graduate School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan.

Mycopathologia
|August 19, 2021
PubMed

Insights

Fungal otitis externa (otomycosis) is rising, often due to antibiotic use disrupting ear flora. This case details a secondary infection involving Candida parapsilosis and Malassezia species, including the newly reported Malassezia obtusa.

Area of Science:

  • Mycology
  • Otolaryngology
  • Infectious Diseases

Background:

  • Fungal otitis externa (otomycosis) is increasingly prevalent.
  • Antibiotic use can disrupt the external auditory canal (EAC) flora, leading to secondary fungal infections.
  • Candida parapsilosis and Malassezia species are known inhabitants of the EAC.

Observation:

  • A case of otomycosis is presented as a secondary infection.
  • The infection followed prolonged treatment with otic ofloxacin.
  • The identified fungi were Candida parapsilosis, Malassezia obtusa, and Malassezia furfur.

Findings:

  • This report details a secondary otomycosis caused by Candida parapsilosis, Malassezia obtusa, and Malassezia furfur.
  • Malassezia obtusa has not been previously reported in human EAC infections.
  • A literature review on Malassezia species in the human EAC was conducted.

Implications:

  • This finding expands the known fungal pathogens associated with otomycosis.
  • Understanding secondary fungal infections is crucial for effective otitis externa treatment.
  • Further research into Malassezia species in the EAC is warranted.
Keywords:
CandidaMalasseziaOfloxacinOtitis externaOtomycosis

More Related Videos

Induction of Ocular Surface Inflammation and Collection of Involved Tissues06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

2.5K
Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

914

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.5K
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
998
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
769