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Updated: Oct 23, 2025
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
Published on: January 7, 2019
Molecularly Imprinted Polymeric Nanoparticles by Precipitation Polymerization and Characterization by Quantitative
Clovia I Holdsworth1, K Fremielle Lim2, Phonlakrit Muang-Non2
1Discipline of Chemistry, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia. clovia.holdsworth@newcastle.edu.au.
Abstract:
An optimized synthetic methodology for the preparation of highly homogeneous MIP nanoparticles by the precipitation method is presented. A quantitative 1H NMR method that was developed to estimate template incorporation, polymer composition and conversion, and binding capacities and selectivities is also described. While the experiment presented here is exemplified by an MIP formulation using (±)-propranolol as the template, methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the crosslinker, the methods and techniques are applicable to other precipitation MIP systems.
