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beta-cell function in children with diabetes.

J Ludvigsson, L G Heding

    Diabetes
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Juvenile diabetes (type 1) may not involve absent insulin secretion at onset. Preserving beta-cell function through early detection and intensive treatment is crucial for metabolic control in children with diabetes.

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    Area of Science:

    • Pediatrics
    • Endocrinology
    • Metabolic Disorders

    Background:

    • Juvenile-onset diabetes (type 1 diabetes) is often presumed to have minimal or absent insulin secretion at diagnosis.
    • Understanding residual beta-cell function is key to managing diabetes in children.

    Purpose of the Study:

    • To investigate the presence and significance of C-peptide levels at the onset of juvenile diabetes.
    • To assess the long-term beta-cell function in juvenile diabetics and its impact on metabolic control.

    Main Methods:

    • Measured C-peptide and proinsulin levels in juvenile diabetic patients at diagnosis and during follow-up.
    • Assessed beta-cell response to breakfast stimulation in patients during remission periods.

    Main Results:

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    • Appreciable C-peptide levels were detected at onset in 12 juvenile diabetic patients, even with ketonuria.
    • Most patients maintained near-normal C-peptide levels during remission, showing responsive beta-cell capacity.
    • Many juvenile diabetics demonstrated persisting beta-cell function, correlating with stable metabolic control.

    Conclusions:

    • Insulin secretion may be present at the onset of juvenile diabetes, contrary to common belief.
    • Early detection and intensive treatment before severe metabolic disturbances may preserve beta-cell function.
    • Sustained beta-cell function is important for achieving stable metabolic control in juvenile diabetes.