ZnI2-Directed Stereocontrolled α-Glucosylation
Siai Zhou1, Xuemei Zhong1, Aoxin Guo2
1School of Pharmaceutical Sciences-Shenzhen, Sun Yat-sen University, Shenzhen 518107, China.
Abstract:
Here we report a glucosylation strategy mediated by ZnI2, a cheap and mild Lewis acid, for the highly stereoselective construction of 1,2-cis-O-glycosidic linkages using easily accessible and common 4,6-O-tethered glucosyl donors. The versatility and effectiveness of the α-glucosylation strategy were demonstrated successfully with various acceptors, including complex alcohols. This approach demonstrates the feasibility of the modular synthesis of various α-glucans with both linear and branched backbone structures.
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