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EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Oct 23, 2025

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

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Published on: June 10, 2021

Modeling schizophrenia with iPS cell technology and disease mouse models.

Takanobu Nakazawa¹

¹Department of Bioscience, Tokyo University of Agriculture, Tokyo, 156-8502, Japan.

Neuroscience Research

|August 19, 2021

Summary

Induced pluripotent stem cell (iPSC) technology allows direct study of patient-derived neuronal cells for schizophrenia research. This approach aids comprehensive interpretation by integrating human and mouse models for cross-species verification.

Keywords:

Disease mouse model Molecular pathology Schizophrenia Translational research iPS cells

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Area of Science:

Neuroscience
Stem Cell Biology
Genetics

Background:

Schizophrenia research is advancing with new technologies.
Induced pluripotent stem cells (iPSCs) offer a unique model system.
Understanding the genetic basis of schizophrenia is crucial.

Purpose of the Study:

To review recent advances in modeling schizophrenia using iPSC technology.
To highlight the utility of disease mouse models in conjunction with iPSCs.
To discuss the integration of iPSC and mouse models for cross-species verification.

Main Methods:

Review of current literature on iPSC technology in schizophrenia research.
Analysis of studies utilizing iPSC-derived neuronal cells from patients.
Examination of comparative studies using disease mouse models.

Main Results:

iPSC technology enables direct analysis of patient-specific neuronal cells.
This technology facilitates comprehensive interpretation by integrating human and animal models.
Cross-species verification is a key benefit of combined modeling approaches.

Conclusions:

iPSC technology is a powerful tool for advancing schizophrenia research.
Integrating iPSC and mouse models enhances understanding of schizophrenia pathophysiology.
Future research should leverage these models for drug discovery and therapeutic development.