Marine peptides in breast cancer: Therapeutic and mechanistic understanding

Area of Science:

• Marine biology
• Biotechnology
• Oncology

Background:

• Breast cancer is a leading cause of cancer deaths in women globally.
• There is an urgent need for novel, effective anti-cancer treatments with reduced toxicity.
• Marine organisms are a potential source of new therapeutic compounds.

Purpose of the Study:

• To review the potential of marine-derived peptides as anti-cancer agents specifically for breast cancer treatment.
• To highlight marine peptides' mechanisms of action against cancer cells.
• To discuss their potential in overcoming multi-drug resistance (MDR) in breast cancer.

Main Methods:

• Literature review of studies on marine peptides and their anti-cancer properties.
• Analysis of research on marine peptide-induced apoptosis, microtubule disruption, and anti-angiogenesis.
• Examination of marine peptides' efficacy against multi-drug resistant breast cancer cell lines.

Main Results:

• Marine peptides exhibit anti-cancer activity through diverse mechanisms, including apoptosis induction and angiogenesis inhibition.
• Several marine peptides have demonstrated efficacy against various cancer types.
• Marine peptides offer a promising avenue for developing breast cancer therapies with potentially lower toxicity than conventional treatments.

Conclusions:

• Marine peptides represent a valuable resource for novel breast cancer therapeutics.
• Further research into marine peptides could lead to treatments that overcome multi-drug resistance and reduce patient side effects.
• Targeting marine-derived compounds is a timely strategy to address the global challenge of breast cancer burden.