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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Factors Affecting Pulmonary Ventilation01:19

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Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Breathing01:05

Breathing

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The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
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Related Experiment Video

Updated: Oct 23, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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The airway microbiome and pediatric asthma.

Rhia Shah1, Supinda Bunyavanich2,3

  • 1Division of Pulmonary Medicine, Department of Pediatrics.

Current Opinion in Pediatrics
|August 19, 2021
PubMed
Summary
This summary is machine-generated.

The airway microbiome, the collection of microbes in airways, is increasingly linked to pediatric asthma. Research shows its role in asthma development, severity, and potential for future risk modification and treatment strategies.

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Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
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Area of Science:

  • Microbiology
  • Pediatric Pulmonology
  • Immunology

Background:

  • Asthma is a prevalent chronic childhood respiratory disease.
  • Recent research highlights the significance of airway microbiome investigations in pediatric asthma.

Purpose of the Study:

  • To review the evolving understanding of the airway microbiome's role in pediatric asthma.
  • To explore the microbiome's influence on asthma development, clinical course, and potential therapeutic targets.

Main Methods:

  • Review of recent studies on upper and lower airway microbiomes in children.
  • Integration of findings from -omics sciences to understand host-microbiome interactions.

Main Results:

  • Microbiome imbalances in the airway are associated with pediatric asthma.
  • Infant airway microbiome may predict later asthma development and is affected by factors like viral infections.
  • Microbiome is linked to asthma exacerbations and control levels.

Conclusions:

  • The airway microbiome offers insights into pediatric asthma diagnosis, prognosis, and treatment.
  • Further research is required to confirm associations and translate findings into clinical practice.